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KMID : 0383820110700020132
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Tuberculosis and Respiratory Diseases
2011 Volume.70 No. 2 p.132 ~ p.138
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Maspin Expression and Its Clinical Significance in Non-Small Cell
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Yoon Seong-Hoon
Kim Won-Jin
Shin Kyung-Hwa
Kim Mi-Hyun
Cho Woo-Hyun
Kim Ki-Uk
Park Hye-Kyung
Jeon Doo-Soo
Kim Yun-Seong
Lee Chang-Hun
Lee Min-Ki
Park Soon-Kew
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Abstract
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Background: Maspin (mammary serine protease inhibitor) is a member of the serpin superfamily. A few studies
have examined the role of maspin in tumor suppression of non-small cell lung cancer (NSCLC); however, its role
in the development and progression of NSCLC still remains controversial. We evaluated the immunohistochemical
expression of maspin in order to elucidate its clinical significance in NSCLC.
Methods: We analyzed 145 patients with pathologically confirmed NSCLC, including 66 cases of squamous cell
carcinomas (SCCs) and 79 cases of adenocarcinomas (ADCs). We performed a immuno-histochemical stain with maspin and PCNA (proliferating cell nuclear antigen) using tissue microarray blocks.
Results: There were 108 men and 37 women in the study population. The mean age of patients in the study
was 63.7 years (range, 40.0∼82.0; median, 65.0). The proportion of maspin expression was significantly higher
in SCCs (52/66, 78.8%; p＜0.01) than in ADCs (17/79, 21.5%; p＜0.01). Maspin expression was not associated
with PCNA (p=0.828), lymph node involvement (p=0.483), or tumor stage (p=0.216), but showed correlation with
well-to-moderate tumor differentiation (p=0.012). There was no observed correlation between maspin expression
and survival with NSCLC (p=0.218).
Conclusion: The present study suggests that maspin expression was significantly higher in SCCs than in ADCs and was associated with low histological grade. However, maspin expression was not an independent factor to predict a prognosis in NSCLC.
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KEYWORD
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Maspin, Non-Small Cell Lung Cancer, Carcinoma, Squamous Cell, Pathology, Prognosis
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